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Article
Anti-Inflammatory Influences on Behavioral, But Not Cortisol, Responses During Maternal Separation
Psychoneuroendocrinology
  • A. M. Perkeybile
  • Patricia A. Schiml-Webb, Wright State University - Main Campus
  • E. O’Brien
  • Terrence Deak
  • Michael B. Hennessy, Wright State University - Main Campus
Document Type
Article
Publication Date
8-1-2009
Abstract
The present study examined the effect of anti-inflammatory agents on the behavioral and plasma cortisol responses of guinea pig pups during isolation in a novel environment. In Experiment 1, intracerebroventricular (ICV) administration of interleukin-10 (IL-10), across a range of doses, significantly reduced passive behaviors of isolated pups. In Experiment 2, neither ICV IL-10 nor alpha-melanocyte stimulating hormone affected the plasma cortisol response to the separation procedure. These results provide further evidence that the passive behaviors of isolated guinea pig pups are mediated by proinflammatory cytokines and indicate that cytokines do not affect behavior indirectly by means of an action on hypothalamic-pituitary-adrenal activity.
DOI
10.1016/j.psyneuen.2009.02.014
Citation Information
A. M. Perkeybile, Patricia A. Schiml-Webb, E. O’Brien, Terrence Deak, et al.. "Anti-Inflammatory Influences on Behavioral, But Not Cortisol, Responses During Maternal Separation" Psychoneuroendocrinology Vol. 34 Iss. 7 (2009) p. 1101 - 1108 ISSN: 0306-4530
Available at: http://works.bepress.com/michael_hennessy/81/