This article describes the service design activities that plan and implement the rail freight operating plan. Elements of strategic service design include the setting of train frequency, the routing of cars among trains, and the consolidation of cars, called blocking. At the operational level, trains are dispatched either according to train paths configured in advance, called timetables, or according to priority rules. We describe the North American and European practice along with selected modeling and problem solving methodologies appropriate for each of the operating conditions described.