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Article
Social influences on clinical outcomes of patients with ovarian cancer
Journal of Clinical Oncology
  • Susan K. Lutgendorf, University of Iowa
  • Koen De Geest, University of Iowa
  • David P. Bender, University of Iowa
  • Amina Ahmed
  • Michael J. Goodheart, University of Iowa
  • Laila Dahmoush
  • M. Bridget Zimmerman
  • Frank J. Penedo
Document Type
Article
Peer Reviewed
1
Publication Date
8-1-2012
NLM Title Abbreviation
J Clin Oncol
Abstract
PURPOSE Previous research has demonstrated relationships of social support with disease-related biomarkers in patients with ovarian cancer. However, the clinical relevance of these findings to patient outcomes has not been established. This prospective study examined how social support relates to long-term survival among consecutive patients with ovarian cancer. We focused on two types of social support: social attachment, a type of emotional social support reflecting connections with others, and instrumental social support reflecting the availability of tangible assistance. PATIENTS AND METHODS Patients were prospectively recruited during a presurgical clinic visit and completed surveys before surgery. One hundred sixty-eight patients with histologically confirmed epithelial ovarian cancer were observed from the date of surgery until death or December 2010. Clinical information was obtained from medical records. Results In a Cox regression model, adjusting for disease stage, grade, histology, residual disease, and age, greater social attachment was associated with a lower likelihood of death (hazard ratio HR], 0.87; 95% CI, 0.77 to 0.98; P = .018). The median survival time for patients with low social attachment categorized on a median split of 15 was 3.35 years (95% CI, 2.56 to 4.15 years). In contrast, by study completion, 59% of patients with high social attachment were still alive after 4.70 years. No significant association was found between instrumental social support and survival, even after adjustment for covariates. CONCLUSION Social attachment is associated with a survival advantage for patients with ovarian cancer. Clinical implications include the importance of screening for deficits in the social environment and consideration of support activities during adjuvant treatment.
Keywords
  • Neoplasms,
  • Glandular and Epithelial -- Psychosocial Factors,
  • Ovarian Neoplasms -- Psychosocial Factors,
  • Support,
  • Psychosocial,
  • Aged,
  • Female,
  • Human,
  • Middle Age,
  • Outcome Assessment,
  • Cox Proportional Hazards Model,
  • Prospective Studies
Published Article/Book Citation

Journal of Clinical Oncology, 30:23 (2012) pp.2885-2890.

Citation Information
Susan K. Lutgendorf, Koen De Geest, David P. Bender, Amina Ahmed, et al.. "Social influences on clinical outcomes of patients with ovarian cancer" Journal of Clinical Oncology Vol. 30 Iss. 23 (2012) p. 2885 - 2890 ISSN: 0732-183X
Available at: http://works.bepress.com/michael_goodheart/41/