H19 is a maternally expressed non-coding RNA located at chromosome 11p15.5 near the reciprocally imprinted insulin-like growth factor 2 (IGF2) gene. Though the function of H19 is unknown, it is transcribed during embryonic development after which transcription is absent in all but a few tissues including cardiac muscle, breast, ovary, uterus, and placenta. Linking H19, miR-675 and RB1 expression with serous tumors of the endometrium suggests that RB1 suppression may be a differentiating event in serous tumorigenesis.
- endometrial cancer,
This work supported in part by NIH 2CA99908-7 and the Department of Obstetrics and Gynecology Research and Development Fund.
Copyright © Eric J. Devor, Jill N. DeMik, Brandon M. Schickling, Michael J. Goodheart, and Kimberly K. Leslie, 2011.
Creative Commons License
Creative Commons Attribution 3.0
Eric J Devor, Jill N. DeMik, Brandon M. Schickling, Michael J. Goodheart, et al.. "H19/miR-675 non-coding RNA expression differentiates among cancers of the human endometrium." Vol. 2 Iss. 1 (2011) p. 1 - 1 ISSN: 2154-4751
Available at: http://works.bepress.com/michael_goodheart/1/