This chapter summarizes mindfulness-based therapies for observe-compulsive disorder (OCD). Mindfulness and acceptance interventions focus on the way in which individuals with OCD address or experience their obsessions, anxiety, uncertainty, and bodily sensations, and how this impacts their behavior. Mindfulness and acceptance interventions include a variety of procedures and treatment packages that center around the common goals of being open, aware, and present with emotional, cognitive, and bodily experiences that can otherwise derail intended actions. Although more evidence is needed, there is sufficient data to suggest that mindfulness and acceptance interventions are reasonable options for the treatment of OCD and related disorders. This chapter summarizes the theory and application of mindfulness and acceptance therapies and the data examining their use for OCD and related disorders.