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Selected Works of Melinda G. Simon
Article
Improving the physiological relevance of drug testing for drug-loaded nanoparticles using 3D tumor cell cultures
MRS Communications (2019)
  • Priya Nimbalkar, San Jose State University
  • Peter Tabada, San Jose State University
  • Anuja Bokare, San José State University
  • Jeffrey Chung, San Jose State University
  • Marzieh Mousavi, San Jose State University
  • Melinda Simon, San Jose State University
  • Folarin Erogbogbo, San Jose State University
Link
Abstract
Nanoparticle-mediated drug delivery has the potential to overcome several limitations of cancer chemotherapy. Lipid polymer hybrid nanoparticles (LPHNPs) have been demonstrated to exhibit superior cellular delivery efficacy. Hence, doxorubicin (a chemotherapeutic drug)-loaded LPHNPs have been synthesized by three-dimensional (3D)-printed herringbone-patterned multi-inlet vortex mixer. This method offers rapid and efficient mixing of reactants yielding controllable and reproducible synthesis of LPHNPs. The cytotoxicity of LPHNPs is tested using two-dimensional (2D) and 3D microenvironments. Results obtained from 3D cell cultures showed major differences in cytotoxicity in comparison with 2D cultures. These results have broad implications in predicting in vitro LPHNP toxicology.
Disciplines
Publication Date
2019
DOI
10.1557/mrc.2019.91
Citation Information
Priya Nimbalkar, Peter Tabada, Anuja Bokare, Jeffrey Chung, et al.. "Improving the physiological relevance of drug testing for drug-loaded nanoparticles using 3D tumor cell cultures" MRS Communications (2019) ISSN: 2159-6859
Available at: http://works.bepress.com/melinda-simon/19/