The study examined the contribution of parental acculturation, parental involvement, and intergenerational relationship to well-being in Filipino American adolescents. Informed by acculturation, ecological, and social capital theories, we hypothesized that immigrant Filipino parents' acculturation would increase their school, home-educational, and social involvement which, in turn, would enhance the family relationship and adolescent outcomes. Using data from the Children of Immigrants Longitudinal Study (CILS), 365 Filipino American adolescents completed surveys and their immigrant parents participated in interviews. Path analysis results showed parental acculturation enhanced their school, home-educational and social involvement. Furthermore, parental home-educational and social involvement enhanced the quality of the intergenerational relationship, which, in turn, increased the adolescents' self-esteem and reduced their depressive symptom level. Implications are discussed.