With the demographic shifts the United States faces, understanding the contributing factors to mental well-being among minority college students is crucial. This study examines the roles of parental and peer attachment, intergenerational conflict, and perceived racial discrimination on depressive symptoms while also analyzing the mediational role of sense of coherence (SOC) on depressive symptoms in Vietnamese American college students. Results from 134 Vietnamese American students surveyed showed that higher levels of parental and peer attachment predicted lower depressive symptoms; SOC partially mediated the effect of parental attachment on depressive symptoms; and SOC played a full mediational role via perceived racial discrimination on depressive symptoms. These findings provide implications for interventions targeting Vietnamese American students at institutions of higher education.