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Randomized controlled study of the urinary excretion of biophenols following acute and chronic intake of olive leaf supplements
Faculty of Informatics - Papers (Archive)
  • Megan Kendall, Charles Sturt University
  • Marijka Batterham, University of Wollongong
  • Damien L Callahan, School of Botany, University of Melbourne
  • Daniel Jardine, Flinders University
  • Paul D Prenzler, Charles Sturt University
  • Kevin Robards, Charles Sturt University
  • Danielle Ryan, Charles Sturt University
RIS ID
38611
Publication Date
1-1-2012
Publication Details

Kendall, M., Batterham, M., Callahan, D. L., Jardine, D., Prenzler, P. D., Robards, K., Ryan, D. (2012). Randomized controlled study of the urinary excretion of biophenols following acute and chronic intake of olive leaf supplements. Food Chemistry, 130 (3), 651-659.

Abstract
Olive leaf supplement was characterised by HPLC and administered to healthy young adults over 28 d (three tablets or equivalent liquid dose per day), or in a single bolus dose of three tablets (or liquid equivalent). Oleuropein was the major biophenol in the extracts. There are no data on the excretion of urinary end-products of the metabolism of the olive leaf biophenols. Following both chronic and acute ingestion neither oleuropein, nor its hydrolysis product, hydroxytyrosol, were detected in urine samples. However, glucuronic acid conjugates, derived from oleuropein aglycone were detected in all urine samples up to 6 h following acute ingestion. The data suggest that oleuropein is bioavailable, which is a necessary pre-condition for bioactivity.
Citation Information
Megan Kendall, Marijka Batterham, Damien L Callahan, Daniel Jardine, et al.. "Randomized controlled study of the urinary excretion of biophenols following acute and chronic intake of olive leaf supplements" (2012) p. 651 - 659
Available at: http://works.bepress.com/mbatterham/56/