![](https://d3ilqtpdwi981i.cloudfront.net/KbT2VXv5kbm8eQVi36oecvAMtW8=/425x550/smart/https://bepress-attached-resources.s3.amazonaws.com/uploads/4d/89/1d/4d891dcd-0b5d-4b66-8596-88df652e3a67/thumbnail_ea64acbf-865e-4e20-a223-0d399b1c72b8.jpg)
Unpublished Paper
Cloning of the complete gene for pig PIT-1 and analysis of PIT-1 protein function
Swine Research Report, 1997
Extension Number
ASL R1492
Topic
Breeding/Physiology
Publication Date
1998
Disciplines
Abstract
We have cloned and sequenced the complete proteincoding region of the pig PIT-1 gene. The pig PIT-1 gene is highly similar to the PIT-1 gene in other species (human, rodent, cattle). We also found some alternative forms of the pig PIT-1 gene. We have analyzed the protein function of the pig PIT-1 genes and one of its alternative forms; D3PIT-1. The functional studies showed that the pig PIT-1 protein can function normally at growth hormone (GH) and prolactin (PRL), whereas the pig D3PIT-1 protein cannot. These results imply that the pig PIT-1 gene is important in pig growth through regulation of GH and PRL gene expression, whereas its alternative forms might play different roles on PIT-1 target genes.
Copyright Owner
Iowa State University
Copyright Date
1998
Language
en
File Format
application/pdf
Citation Information
T.-P. Yu, H. S. Sun, Max F. Rothschild and C. K. Tuggle. "Cloning of the complete gene for pig PIT-1 and analysis of PIT-1 protein function" (1998) Available at: http://works.bepress.com/max-rothschild/135/