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Selected Works of Max Bulsara
Contribution to Book
A risk-adapted approach to breast radiation using Targeted Intraoperative Radiotherapy (TARGIT)
Short course breast radiotherapy: a comprehensive review of hypofractionation, partial breast, and intra-operative irradiation (2016)
  • Jayant S Vaidya, University College London
  • Jeffrey Tobias, University College London
  • Frederik Wenz, University of Heidelberg
  • Samuele Massarut, Centro di Riferimento Oncologia
  • Max Bulsara, The University of Notre Dame Australia
  • Christobel Saunders, The University of Western Australia
  • Henrik Flyger, University of Copenhagen
  • Michael Alvarado, University of California
  • Wolfgang Eiermann, Red Cross Hospital
  • Tammy Corica, Sir Charles Gairdner Hospital
  • David Joseph, Sir Charles Gairdner Hospital
  • Michael Baum, University College London
Abstract
Whole-organ detailed three-dimensional pathological analysis of mastectomy specimens vis-à-vis the results of breast-conserving surgery trials demonstrates a remarkable phenomenon: in addition to the main tumor, the mastectomy specimen reveals often multiple foci of cancer distributed widely in the breast volume. This is in contrast with the location of a local recurrence, which mostly occurs in the area around the original tumor – thus, it makes sense to focus radiation only around the original tumor. Based on this insight, the targeted intraoperative radiotherapy technique and the device to deliver it were developed in the late 1990s, the first case treated at the Middlesex Hospital, University College London, UK, on 2 July 1998. Pilot studies confirmed feasibility and safety, and in March 2000, the TARGIT-A randomized trial was launched.
Disciplines
Publication Date
2016
Editor
Douglas W Arthur, Frank A. Vicini, David E. Wazer, Atif J. Khan
Publisher
Springer
ISBN
978-3-319-24388-7
DOI
10.1007/978-3-319-24388-7_21
Citation Information
Vaidya, J., Tobias, J., Wenz, F., Massarut, S., Bulsara, M., Saunders, C., Flyger, H., Alvarado, M., Eiermann, W., Corica, T., Joseph, D., and Baum, M. (2016). A risk-adapted approach to breast radiation using Targeted Intraoperative Radiotherapy (TARGIT). In D.W. Arthur, F.A. Vicini, D.E. Wazer, A.J. Khan (eds), Short course breast radiotherapy: a comprehensive review of hypofractionation, partial breast, and intra-operative irradiation. Springer: Online, p. 327-346. DOI: 10.1007/978-3-319-24388-7_21