Article
Mouse chromosome fragility
American Jouranl of Medical Genetics
(1986)
Abstract
When cultures of fibroblast‐like cells from inbred mouse strains RBC/Dn and AEJ/GnRk were exposed to 5‐fluoro‐deoxyuridine (FUdR), non‐random strain‐specific distributions of chromosome gaps, breaks and exchanges were observed. Throughout the genomes there appeared to be specific sites at which lesions occurred preferentially. Two strain‐specific fragile sites were identified in strain RBC/Dn at G‐band 15A2, and at G‐band 19B in strain AEJ/GnRk. Constitutive fragile sites at G‐bands 12A2 and 18A2 were identified in both strains. A strain‐specific marker at G‐band 9B was found in strain AEJ/GnRk. The fragile sites reported here provide an animal model for the study of chromosome fragility as well as polymorphic markers for linkage studies.
Disciplines
Publication Date
January, 1986
Citation Information
Maureen M Sanz, Edmund C. Jenkins, W. Ted Brown, Muriel T. Davisson, et al.. "Mouse chromosome fragility" American Jouranl of Medical Genetics Vol. 23 Iss. 1-2 (1986) p. 491 - 509 Available at: http://works.bepress.com/maureen-sanz/15/