Organizations that are acquired are done so with the intention of improving the economic position of the principals, yet, there are stakeholders who are negatively affected by a change in leadership due to a merger or an acquisition. How a company is assumed or acquired may have a positive impact on shareholders, but a negative impact on employees. The human aspect of mergers and acquisitions, and its impact on people and performance, is the focus of this paper. The authors will discuss the business related human behaviors such as management resistance, employee resistance, organizational transition, communication, and leadership’s role.