More than 250,000 patients undergo cardiac surgery every year. Although advances in surgical techniques have reduced the peri-operative morbidity and mortality in these patients, atrial fibrillation persists to commonly occur following these surgeries. Traditional therapies have reduced their occurrence; however there are still a significant number of patients who develop this complication. Newer and non-conventional medications are being studied to reduce this cardiac arrhythmia. This review will elaborate on the patho-physiology, and prevention of this arrhythmia. We also aim to summarize recent investigated and patented medications which may result in more effective strategies for prophylaxis against this cardiac arrhythmia.
Shariff, N., Aleem, A., Jacobs, L. E., Cutitta, C., Siddique, S. M., Martinez, M. W., & ... Freudenberger, R. (2011). Atrial fibrillation following cardiac surgery: established and emerging strategies of prevention. Recent Patents On Cardiovascular Drug Discovery, 6(3), 168-174.