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Ivabradine: Heart Failure and Beyond
Journal of cardiovascular pharmacology and therapeutics
  • Rahul Chaudhary, MD
  • Jalaj Garg, MD, Lehigh Valley Health Network
  • Parasuram Krishnamoorthy, MD
  • Neeraj Shah, MD, Lehigh Valley Health Network
  • Gregg Lanier
  • Matthew W Martinez, MD, Lehigh Valley Health Network
  • Ronald S Freudenberger, MD, Lehigh Valley Health Network
Publication/Presentation Date

Heart failure affects over 5 million people in the United States and carries a high rate of mortality. Ivabradine, a new agent has been added to the current medical options for managing heart failure. It is a selective funny current (I f) inhibitor in sinoatrial node and slows its firing rate, prolonging diastolic depolarization without a negative inotropic effect. Ivabradine was only recently approved by Food and Drug administration after the results of Systolic Heart Failure Treatment with the I f Inhibitor Ivabradine (SHIFT) trial, for a reduction in rehospitalizations from chronic heart failure. This trial assessed patients with stable heart failure with reduced ejection fraction and a heart rate of at least 70 beats per minute at rest on maximally tolerated beta-blocker therapy and demonstrated statistically significant reduction in heart failure hospitalization and deaths. Additionally, ivabradine has been associated with reduced cardiac remodeling, reduced heart rate variability, improvement in exercise tolerance, improved heart failure class of New York Heart Association, and better quality of life. It has also been tried in other conditions, such as inappropriate sinus tachycardia and cardiogenic shock, and is currently in phase II trial for patients with newly diagnosed multiple organ dysfunction syndrome.

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Citation Information

Chaudhary, R., Garg, J., Krishnamoorthy, P., Shah, N., Lanier, G., Martinez, M. W., & Freudenberger, R. (2015). Ivabradine: Heart Failure and Beyond. Journal Of Cardiovascular Pharmacology And Therapeutics. 21(4), 335-343. doi:10.1177/1074248415624157