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Article
Ivabradine: Heart Failure and Beyond
Journal of cardiovascular pharmacology and therapeutics
  • Rahul Chaudhary, Sinai Hospital of Baltimore, Johns Hopkins University, Baltimore, MD
  • Jalaj Garg, MD, Lehigh Valley Health Network
  • Parasuram Krishnamoorthy, Englewood Hospital and Medical Center, Mount Sinai School of Medicine, Englewood, NJ
  • Neeraj Shah, MD, Lehigh Valley Health Network
  • Gregg Lanier, Westchester Medical Center, New York Medical College, Valhalla, NY
  • Matthew W Martinez, MD, Lehigh Valley Health Network
  • Ronald S Freudenberger, MD, Lehigh Valley Health Network
Publication/Presentation Date
12-31-2015
Abstract

Heart failure affects over 5 million people in the United States and carries a high rate of mortality. Ivabradine, a new agent has been added to the current medical options for managing heart failure. It is a selective funny current (I f) inhibitor in sinoatrial node and slows its firing rate, prolonging diastolic depolarization without a negative inotropic effect. Ivabradine was only recently approved by Food and Drug administration after the results of Systolic Heart Failure Treatment with the I f Inhibitor Ivabradine (SHIFT) trial, for a reduction in rehospitalizations from chronic heart failure. This trial assessed patients with stable heart failure with reduced ejection fraction and a heart rate of at least 70 beats per minute at rest on maximally tolerated beta-blocker therapy and demonstrated statistically significant reduction in heart failure hospitalization and deaths. Additionally, ivabradine has been associated with reduced cardiac remodeling, reduced heart rate variability, improvement in exercise tolerance, improved heart failure class of New York Heart Association, and better quality of life. It has also been tried in other conditions, such as inappropriate sinus tachycardia and cardiogenic shock, and is currently in phase II trial for patients with newly diagnosed multiple organ dysfunction syndrome.

PubMedID
26721645
Document Type
Article
Citation Information

Chaudhary, R., Garg, J., Krishnamoorthy, P., Shah, N., Lanier, G., Martinez, M. W., & Freudenberger, R. (2015). Ivabradine: Heart Failure and Beyond. Journal Of Cardiovascular Pharmacology And Therapeutics. 21(4), 335-343. doi:10.1177/1074248415624157