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Article
Speckle Myocardial Imaging Modalities for Early Detection of Myocardial Impairment in Isolated Left Ventricular Non-Compaction
Heart (British Cardiac Society)
  • Diego Bellavia, Mayo Clinic and Foundation
  • Hector I Michelena, Mayo Clinic and Foundation
  • Matthew W Martinez, Lehigh Valley Health Network
  • Patricia A Pellikka, Mayo Clinic and Foundation
  • Charles J Bruce, Mayo Clinic and Foundation
  • Heidi M Connolly, Mayo Clinic and Foundation
  • Hector R Villarraga, Mayo Clinic and Foundation
  • Gabriella Veress, Mayo Clinic and Foundation
  • Jae K Oh, Mayo Clinic and Foundation
  • Fletcher A Miller, Mayo Clinic and Foundation
Publication/Presentation Date
3-1-2010
Abstract
OBJECTIVE: To examine the hypothesis that speckle myocardial imaging (SMI) modalities, including longitudinal, radial and circumferential systolic (s) and diastolic (d) myocardial velocity imaging, displacement (D), strain rate (SR) and strain (S), as well as left ventricular (LV) rotation/torsion are sensitive for detecting early myocardial dysfunction in isolated LV non-compaction (iLVNC). DESIGN AND RESULTS: Twenty patients with iLVNC diagnosed by cardiac magnetic resonance (15) or echocardiography (5) were included. Patients were divided into two groups: ejection fraction (EF)>50% (n=10) and EF50%). However, SMI-derived longitudinal sS, sSR, sD and radial sS, as well as LV rotation/torsion values, were all reduced in iLVNC (EF>50%) compared with controls. Measurements with the highest discriminating power between iLVNC (EF>50%) and controls were longitudinal sS mean of the six apical segments (area under the curve (AUC)=0.94), sS global average (AUC=0.94), LV rotation apical mean (AUC=0.94); LV torsion (AUC=0.93) LV torsion rate (AUC=0.94). CONCLUSIONS: LV SMI values are reduced in patients with iLVNC, even those with normal EF and PWTDI. The most accurate SMI modalities to discriminate between patients and controls are longitudinal sS mean of the six apical segments, LV apical rotation or LV torsion rate.
PubMedID
19966109
Document Type
Article
Citation Information

Bellavia, D., Michelena, H. I., Martinez, M., Pellikka, P. A., Bruce, C. J., Connolly, H. M., & ... Miller, F. A. (2010). Speckle myocardial imaging modalities for early detection of myocardial impairment in isolated left ventricular non-compaction. Heart (British Cardiac Society), 96(6), 440-447. doi:10.1136/hrt.2009.182170.