Background: Myogenic tone, the ability of vascular smooth muscle to adapt its contractility to changes in transmural pressure, is known to be present in resistance vessels in a number of vascular beds. Myogenic tone is a component of autoregulation. Controversy exists over whether mesenteric resistance vessels even possess myogenic tone. There have been several factors shown to modulate myogenic tone in different vascular beds. High glucose has been shown to cause a greater vasoconstriction in some vascular beds and vasodilation in others. A role for protein kinase C (PKC) in the development of myogenic tone has been shown in several vascular beds. Prostaglandins have been implicated in the modulation of myogenic tone in some vascular beds.
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