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Article
Comparison of Piperacillin/Tazobactam and Imipenem/Cilastatin, both in Combination with Tobramycin, Administered Every 6h for Treatment of Nosocomial Pneumonia
Respiratory Medicine
  • Manjari Joshi
  • Michael Metzler
  • Mary C. McCarthy, Wright State University
  • Stephen Olvey
  • Wedad Kassira
  • Angel Cooper
Document Type
Article
Publication Date
9-1-2006
Abstract
This randomized, double-blind, multicenter study compared the efficacy and safety of piperacillin/tazobactam (P/T) and imipenem/cilastatin (IMP), both in combination with an aminoglycoside, in hospitalized patients with acute nosocomial pneumonia (NP). Patients with acute NP, defined as pneumonia with symptoms ⩾48 h after admission or ⩽7 days after hospital discharge, received infusions of 4 g/500 mg P/T or 500 mg/500 mg IMP every 6 h. Endpoints were clinical cure and microbiological response rates; pathogen eradication rates; length of hospital stay; hospital readmissions; and adverse events (AEs). Of 437 patients in the intent-to-treat population, 197 were efficacy evaluable. At test-of-cure, response rates were similar between groups. Within the efficacy evaluable population, 68% of P/T patients and 61% of IMP patients were clinically cured (P=0.256P=0.256). Microbiological responses for P/T and IMP patients were: eradication, 64% versus 59%; persistence, 29% versus 21%; relapse, 0% versus 5%; and superinfection, 7% versus 15%, respectively. Gram-positive isolates were eradicated in 83% of P/T patients and 75% of IMP patients; Gram-negative pathogens were eradicated in 72% of P/T patients and 77% of IMP patients. Treatment groups had similar number of mean hospital days, readmission rates, and frequency of AEs. This study showed that P/T administered four times per day was as safe and efficacious as IMP in treating hospitalized patients with NP.
DOI
10.1016/j.rmed.2006.01.004
Citation Information
Manjari Joshi, Michael Metzler, Mary C. McCarthy, Stephen Olvey, et al.. "Comparison of Piperacillin/Tazobactam and Imipenem/Cilastatin, both in Combination with Tobramycin, Administered Every 6h for Treatment of Nosocomial Pneumonia" Respiratory Medicine Vol. 100 Iss. 9 (2006) p. 1554 - 1565 ISSN: 0954-6111
Available at: http://works.bepress.com/mary_mccarthy/92/