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Article
Single-Cell Squamous Carcinoma: An Underreported High-Risk Variant
University of Massachusetts Medical School Faculty Publications
  • Amanda Auerbach, University of Massachusetts Medical School
  • Patrick Mulvaney, University of Massachusetts Medical School
  • Dori Goldberg, University of Massachusetts Medical School
  • Elizabeth Foley, University of Massachusetts Medical School
  • Mary E. Maloney, University of Massachusetts Medical School
UMMS Affiliation
Department of Medicine, Division of Dermatology
Date
1-1-2016
Document Type
Article
Abstract

BACKGROUND: There is increasing interest in establishing diagnostic and treatment guidelines for high-risk squamous cell carcinoma (SCC). Single-cell SCC has been recognized as a high-risk subtype but continues to be a less commonly reported and more poorly understood variant.

OBJECTIVE: To present the current literature on single-cell SCC.

MATERIALS AND METHODS: A review of the literature on single-cell squamous cell carcinoma.

RESULTS: There are fewer than 100 cases of single-cell SCC in the literature. The reporting studies demonstrate an increase in the risk of metastasis compared with non-single-cell tumors. Confounding variables reported include other coexisting high-risk features: diameter > 2 cm, depth > 6 mm, and difficulty detecting single tumor cells. It is therefore unclear whether single-cell SCC is an independent risk factor for recurrence and regional spread. Studies have described use of immunostaining as a means to improve tumor detection.

CONCLUSION: Single-cell SCC continues to be an underreported SCC variant. Given its apparent aggressive behavior, more studies are warranted to better understand its tumor biology and behavior and to improve patient outcomes. Based on our present knowledge, complete tumor excision with or without the aid of immunostaining and use of multidisciplinary care are recommended.

Rights and Permissions
Citation: Dermatol Surg. 2016 Jan;42 Suppl 1:S2-7. doi: 10.1097/DSS.0000000000000574. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
26730970
Citation Information
Amanda Auerbach, Patrick Mulvaney, Dori Goldberg, Elizabeth Foley, et al.. "Single-Cell Squamous Carcinoma: An Underreported High-Risk Variant" Vol. 42 Suppl 1 (2016) ISSN: 1076-0512 (Linking)
Available at: http://works.bepress.com/mary_maloney/55/