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Article
Pigmented basal cell carcinoma: investigation of 70 cases
Dermatology Publications and Presentations
  • Mary E. Maloney, University of Massachusetts Medical School
  • Daniel B. Jones, Pennsylvania State University
  • F. Mack Sexton, Pennsylvania State University
UMMS Affiliation
Department of Medicine, Division of Dermatology
Date
7-1-1992
Document Type
Article
Medical Subject Headings
Biopsy; Carcinoma, Basal Cell; Humans; Melanins; Melanocytes; Skin; Skin Neoplasms; Staining and Labeling
Abstract
BACKGROUND: Pigmented basal cell carcinoma (PBCC) is a clinical and histologic variant of BCC. OBJECTIVE: Our purpose was to identify the histologic subtypes of BCC that were most often associated with pigment and to determine whether this correlated with outcome after excision. METHODS: A series of PBCC was identified and the histologic subtype noted. Margins of all excisions were examined for residual tumor. These results were then compared with a series of nonpigmented BCCs. RESULTS: In a series of 1039 consecutive BCCs, 70 (6.7%) contained pigment. The histologic growth pattern most frequently associated with pigment was the nodular/micronodular pattern (12.4%) followed by the nodular (7.7%), superficial (7.2%), micronodular (4.0%), and the nodular/micronodular/infiltrative (3.4%) patterns. Margins were examined for evidence of residual tumor in the 40 cases that were excised. In only one case (2.5%) was the margin positive for tumor. This was statistically significant (p less than 0.05) compared with 388 excisions of nonpigmented BCCs with comparable growth patterns in which 69 (17.7%) showed positive margins. CONCLUSION: PBCC, as a clinical variant, is more frequently excised with adequate margins than are tumors of comparable histologic subtypes that do not contain pigment.
Comments

Citation: J Am Acad Dermatol. 1992 Jul;27(1):74-8. doi:10.1016/0190-9622(92)70160-H

At the time of publication, Mary E. Maloney was not yet affiliated with the University of Massachusetts Medical School.

Related Resources
Link to Article in PubMed
PubMed ID
1377719
Citation Information
Mary E. Maloney, Daniel B. Jones and F. Mack Sexton. "Pigmented basal cell carcinoma: investigation of 70 cases" Vol. 27 Iss. 1 (1992) ISSN: 0190-9622 (Linking)
Available at: http://works.bepress.com/mary_maloney/5/