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Pigmented basal cell carcinoma: investigation of 70 cases
Dermatology Publications and Presentations
  • Mary E. Maloney, University of Massachusetts Medical School
  • Daniel B. Jones, Pennsylvania State University
  • F. Mack Sexton, Pennsylvania State University
UMMS Affiliation
Department of Medicine, Division of Dermatology
Publication Date
Document Type
Biopsy; Carcinoma, Basal Cell; Humans; Melanins; Melanocytes; Skin; Skin Neoplasms; Staining and Labeling
BACKGROUND: Pigmented basal cell carcinoma (PBCC) is a clinical and histologic variant of BCC. OBJECTIVE: Our purpose was to identify the histologic subtypes of BCC that were most often associated with pigment and to determine whether this correlated with outcome after excision. METHODS: A series of PBCC was identified and the histologic subtype noted. Margins of all excisions were examined for residual tumor. These results were then compared with a series of nonpigmented BCCs. RESULTS: In a series of 1039 consecutive BCCs, 70 (6.7%) contained pigment. The histologic growth pattern most frequently associated with pigment was the nodular/micronodular pattern (12.4%) followed by the nodular (7.7%), superficial (7.2%), micronodular (4.0%), and the nodular/micronodular/infiltrative (3.4%) patterns. Margins were examined for evidence of residual tumor in the 40 cases that were excised. In only one case (2.5%) was the margin positive for tumor. This was statistically significant (p less than 0.05) compared with 388 excisions of nonpigmented BCCs with comparable growth patterns in which 69 (17.7%) showed positive margins. CONCLUSION: PBCC, as a clinical variant, is more frequently excised with adequate margins than are tumors of comparable histologic subtypes that do not contain pigment.
DOI of Published Version

J Am Acad Dermatol. 1992 Jul;27(1):74-8. doi:10.1016/0190-9622(92)70160-H


At the time of publication, Mary E. Maloney was not yet affiliated with the University of Massachusetts Medical School.

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Link to Article in PubMed
PubMed ID
Citation Information
Mary E. Maloney, Daniel B. Jones and F. Mack Sexton. "Pigmented basal cell carcinoma: investigation of 70 cases" Vol. 27 Iss. 1 (1992) ISSN: 0190-9622 (Linking)
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