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Cell surface molecules in basal cell carcinomas
Dermatology Publications and Presentations
  • Mary Pentel, Pennsylvania State University
  • Klaus F. Helm, Pennsylvania State University
  • Mary E. Maloney, University of Massachusetts Medical School
UMMS Affiliation
Department of Medicine, Division of Dermatology
Publication Date
Document Type
Adult; Aged; Carcinoma, Basal Cell; Cell Adhesion Molecules; Female; Humans; Immunoglobulins; Integrins; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Selectins; Skin Neoplasms

BACKGROUND: The factors determining a basal cell carcinoma's (BCC's) growth pattern and invasive potential are not known. In other tumors it has been shown recently that the expression of cellular adhesion molecules may determine a tumor's invasive and metastatic potential. Integrins, cell surface molecules important in cell stroma interactions, are present on BCCs and may help regulate the tumor's growth pattern.

OBJECTIVE: We compared the expression of cellular adhesion molecules alpha 2 integrin, beta 1 integrin, intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), leukocyte function antigen 1a (LFA-1a), and E-selectin in different histological subtypes of basal cell carcinomas.

METHODS: BCCs were obtained from patients undergoing Mohs surgery. The BCCs were classified as nodular, micronodular, mixed, infiltrative, and basosquamous types and stained using an avidin-biotin-immunoperoxidase technique with antibodies against alpha 2 integrin, beta 1 integrin, ICAM, LFA-1a, VCAM-1, and E-selectin.

RESULTS: BCCs expressed alpha 2 and beta 1 integrin, but no significant differences in the amount or pattern of expression was seen in the different histologic subtypes.

CONCLUSION: The expression of integrins by BCCs by binding to the surrounding stroma may limit BCC's growth; however, their expression does not appear to correlate with their histological pattern.

DOI of Published Version

Dermatol Surg. 1995 Oct;21(10):858-61. doi:10.1111/j.1524-4725.1995.tb00712.x


At the time of publication, Mary E. Maloney was not yet affiliated with the University of Massachusetts Medical School.

Related Resources
Link to Article in PubMed
PubMed ID
Citation Information
Mary Pentel, Klaus F. Helm and Mary E. Maloney. "Cell surface molecules in basal cell carcinomas" Vol. 21 Iss. 10 (1995) ISSN: 1076-0512 (Linking)
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