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Association between chlorinated pesticides in the serum of prepubertal Russian boys and longitudinal biomarkers of metabolic function
  • Jane S. Burns, Harvard University
  • Paige L. Williams, Harvard University
  • Susan A. Korrick, Harvard University
  • Russ Hauser, Harvard University
  • Oleg Sergeyev, Samara State University
  • Boris Revich, Russian Academy of Sciences
  • Thuy Lam, Harvard University
  • Mary M. Lee, University of Massachusetts Medical School
UMMS Affiliation
Department of Pediatrics; Department of Cell and Developmental Biology
Publication Date
Document Type
Adolescent; Biological Markers; Blood Glucose; Child; Cholesterol; Humans; Hydrocarbons, Chlorinated; Insulin; *Insulin Resistance; Leptin; Male; Metabolic Syndrome X; Pesticides; Prospective Studies; Regression Analysis; Triglycerides

Organochlorine pesticides (OCPs) have been linked to adult metabolic disorders; however, few studies have examined these associations in childhood. We prospectively evaluated the associations of baseline serum OCPs (hexachlorobenzene, beta-hexachlorocyclohexane, and p,p'-dichlorodiphenyldichloroethylene) in Russian boys with subsequent repeated measurements of serum glucose, insulin, lipids, leptin, and calculated homeostatic model assessment of insulin resistance (IR). During 2003-2005, we enrolled 499 boys aged 8-9 years in a prospective cohort; 318 had baseline serum OCPs and serum biomarkers measured at ages 10-13 years. Multivariable generalized estimating equation and mediation regression models were used to examine associations and direct and indirect (via body mass index (BMI) (weight (kg)/height (m)(2))) effects of prepubertal OCP tertiles and quintiles with biomarkers. In multivariable models, higher p,p'-dichlorodiphenyldichloroethylene (quintile 5 vs. quintile 1) was associated with lower leptin, with relative mean decreases of 61.8% (95% confidence interval: 48.4%, 71.7%) in models unadjusted for BMI and 22.2% (95% confidence interval: 7.1%, 34.9%) in models adjusted for BMI; the direct effect of p,p'-dichlorodiphenyldichloroethylene on leptin accounted for 27% of the total effect. IR prevalence was 6.6% at ages 12-13 years. Higher hexachlorobenzene (tertile 3 vs. tertile 1) was associated with higher odds of IR in models adjusted for BMI (odds ratio = 4.37, 95% confidence interval: 1.44, 13.28). These results suggest that childhood OCPs may be associated with IR and lower leptin.

  • children,
  • insulin resistance,
  • leptin,
  • metabolism,
  • pesticides
DOI of Published Version
Am J Epidemiol. 2014 Nov 1;180(9):909-19. doi: 10.1093/aje/kwu212. Epub 2014 Sep 25. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
Citation Information
Jane S. Burns, Paige L. Williams, Susan A. Korrick, Russ Hauser, et al.. "Association between chlorinated pesticides in the serum of prepubertal Russian boys and longitudinal biomarkers of metabolic function" Vol. 180 Iss. 9 (2014) ISSN: 0002-9262 (Linking)
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