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Serum dioxins and polychlorinated biphenyls are associated with growth among Russian boys
Lee Lab
  • Jane S. Burns, Harvard University
  • Paige L. Williams, Harvard School of Public Health
  • Oleg Sergeyev, Samara State Medical University
  • Susan Korrick, Harvard Medical School
  • Mary M. Lee, University of Massachusetts Medical School
  • Boris Revich, Russian Academy of Sciences
  • Larisa Altshul, Environmental Health and Engineering, Inc.
  • Julie T. Del Prato, Harvard School of Public Health
  • Olivier Humblet, Harvard School of Public Health
  • Donald G. Patterson, Jr., EnviroSolutions Consulting, Inc.
  • Wayman E. Turner, Centers for Disease Control and Prevention
  • Larry L. Needham, Centers for Disease Control and Prevention
  • Mikhail Starovoytov, Russian Institute of Nutrition
  • Russ Hauser, Harvard School of Public Health
UMMS Affiliation
Department of Pediatrics; Department of Cell Biology
Date
1-29-2011
Document Type
Article
Medical Subject Headings
Child; Dioxins; Environmental Exposure; Follow-Up Studies; *Growth; Humans; Male; Polychlorinated Biphenyls; Prospective Studies; Russia
Disciplines
Abstract
OBJECTIVE: We evaluated the associations of serum dioxins and polychlorinated biphenyls (PCBs) with longitudinally assessed growth measurements among peripubertal Russian boys. METHODS: A total of 499 boys from Chapaevsk, Russia, aged 8 to 9 years were enrolled in the study from 2003 to 2005 and were followed prospectively for 3 years. Blood samples were collected and physical examinations were conducted at entry and repeated at annual study visits. Multivariate mixed-effects regression models for repeated measures were used to examine the associations of serum dioxins and PCBs with longitudinal measurements of BMI, height, and height velocity. RESULTS: Serum dioxin (total 2005 toxic equivalency [TEQ] median: 21.1 pg/g lipid) and PCBs (median sum of PCBs: 250 ng/g lipid) were measured in 468 boys. At study entry and during 3 years of follow-up, >50% of the boys had age-adjusted BMI and height z scores within 1 SD of World Health Organization-standardized mean values for age. Boys in the highest exposure quintile of the sum of dioxin and PCB concentrations and total TEQs had a significant decrease in mean BMI z scores of 0.67 for dioxins and TEQs and 1.04 for PCBs, compared with boys in the lowest exposure quintile. Comparison of the highest versus the lowest quintile revealed that higher serum PCB concentrations were associated with significantly lower height z scores (mean z-score decrease: 0.41) and height velocity (mean decrease: 0.19 cm/year) after 3 years of follow-up. CONCLUSIONS: Our findings suggest that exposures to dioxins and PCBs are associated with reduced growth during the peripubertal period and may compromise adult body mass, stature, and health.
Rights and Permissions
Citation: Pediatrics. 2011 Jan;127(1):e59-68. Epub 2010 Dec 27. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
21187307
Citation Information
Jane S. Burns, Paige L. Williams, Oleg Sergeyev, Susan Korrick, et al.. "Serum dioxins and polychlorinated biphenyls are associated with growth among Russian boys" Vol. 127 Iss. 1 (2011) ISSN: 0031-4005 (Linking)
Available at: http://works.bepress.com/mary_lee/79/