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Predictors of serum chlorinated pesticide concentrations among prepubertal Russian boys
Lee Lab Publications
  • Thuy Lam, Harvard School of Public Health
  • Paige L. Williams, Harvard School of Public Health
  • Jane S. Burns, Harvard School of Public Health
  • Oleg Sergeyev, Samara State Medical University
  • Susan Korrick, Harvard School of Public Health
  • Mary M. Lee, University of Massachusetts Medical School
  • Linda S. Birnbaum, National Institutes of Health
  • Boris Revich, Russian Academy of Sciences
  • Larisa Altshul, Harvard School of Public Health
  • Donald G. Patterson, EnviroSolutions Consulting, Inc.
  • Wayman E. Turner, Centers for Disease Control and Prevention
  • Russ Hauser, Harvard School of Public Health
UMMS Affiliation
Department of Pediatrics
Date
11-1-2013
Document Type
Article
Abstract
BACKGROUND: Few studies have evaluated predictors of childhood exposure to organochlorine pesticides (OCPs), a class of lipophilic persistent chemicals. OBJECTIVES: Our goal was to identify predictors of serum OCP concentrations-hexachlorobenzene (HCB), beta-hexachlorocyclohexane (beta-HCH), and p,p-dichlorodiphenyldichloroethylene (p,p -DDE)-among boys in Chapaevsk, Russia. METHODS: Between 2003 and 2005, 499 boys 8-9 years of age were recruited in a prospective cohort. The initial study visit included a physical examination; blood collection; health, lifestyle, and food-frequency questionnaires; and determination of residential distance from a local factory complex that produced HCB and beta-HCH. Fasting serum samples were analyzed for OCPs at the U.S. Centers for Disease Control and Prevention. General linear regression models were used to identify predictors of the boys' serum HCB, beta-HCH, and p,p -DDE concentrations. RESULTS: Among 355 boys with OCP measurements, median serum HCB, beta-HCH, and p,p -DDE concentrations were 158, 167, and 284 ng/g lipid, respectively. Lower body mass index, longer breastfeeding duration, and local dairy consumption were associated with higher concentrations of OCPs. Boys who lived < 2 km from the factory complex had 64% (95% CI: 37, 96) and 57% (95% CI: 32, 87) higher mean HCB and beta-HCH concentrations, respectively, than boys who lived >/= 5 km away. Living > 3 years in Chapaevsk predicted higher beta-HCH concentrations, and having parents who lacked a high school education predicted higher p,p -DDE concentrations. CONCLUSIONS: Among this cohort of prepubertal Russian boys, predictors of serum OCPs included consumption of local dairy products, longer local residence, and residential proximity to the local factory complex.
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Citation: Environ Health Perspect. 2013 Nov-Dec;121(11-12):1372-7. doi: 10.1289/ehp.1306480. Epub 2013 Aug 15. Link to article on publisher's site
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Reproduced with permission from Environmental Health Perspectives.

Related Resources
Link to Article in PubMed
PubMed ID
23955839
Citation Information
Thuy Lam, Paige L. Williams, Jane S. Burns, Oleg Sergeyev, et al.. "Predictors of serum chlorinated pesticide concentrations among prepubertal Russian boys" Vol. 121 Iss. 11-12 (2013) ISSN: 0091-6765 (Linking)
Available at: http://works.bepress.com/mary_lee/77/