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Article
Hepatic dysfunction is associated with vitamin D deficiency and poor glycemic control in diabetes mellitus
Endocrinology/Diabetes
  • Benjamin U. Nwosu, University of Massachusetts Medical School
  • Zheni G. Stavre, University of Massachusetts Medical School
  • Louise Maranda, University of Massachusetts Medical School
  • Karen Cullen, University of Massachusetts Medical School
  • Mary M. Lee, University of Massachusetts Medical School
UMMS Affiliation
Department of Pediatrics; Department of Medicine
Date
1-25-2012
Document Type
Article
Medical Subject Headings
Vitamin D Deficiency; Diabetes Mellitus; Fatty Liver
Abstract
Background/Aims: The effect of the rising prevalence of nonalcoholic fatty liver disease on the 25-hydroxylation of pre-vitamin D in the liver, and consequent glycemic control in children with diabetes mellitus is not known. Our aim was to determine whether mild hepatic dysfunction was associated with impaired 25-hydroxylation of pre-vitamin D, and if this vitamin D deficiency was associated with impaired glycemic control in children and adolescents with type 1 diabetes (TIDM) and type 2 diabetes (T2DM). Methods: We analyzed simultaneously measured HbA1c, ALT, AST, and 25OHD levels and clinical parameters in 121 children and adolescents with T1DM (n=81) and T2DM (n=40). The subjects, ages 11–21 years, all had diabetes of >6 months duration. Multivariate linear regression was used to analyze the associations, while comparisons between subgroups were made using two-tailed Student’s t-test. Results: Vitamin D deficiency (25OHD/mL (37.5 nmol/L) was more prevalent in T2DM patients (47.5%) compared to T1DM patients (18.5%). Subjects with T2DM had significantly elevated transaminases (AST 39.3±2.0 vs. 22.4±1.4, p Conclusions: The association of elevated ALT with vitamin D deficiency suggests that hepatic dysfunction could impair vitamin D metabolism and negatively impact glycemic control in youth with T2DM.
Comments

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 25, Issue 1-2, Pages 181–186, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem-2011-0403, January 2012.

Medical student Zheni Stavre participated in this study as part of the Senior Scholars research program.

A blog post about this research from the Vitamin D Council is available below as an Additional File.

Keywords
  • glycemia,
  • hepatic dysfunction,
  • type 1 diabetes,
  • type 2 diabetes,
  • vitamin D deficiency
Citation Information
Benjamin U. Nwosu, Zheni G. Stavre, Louise Maranda, Karen Cullen, et al.. "Hepatic dysfunction is associated with vitamin D deficiency and poor glycemic control in diabetes mellitus" Vol. 25 Iss. 1-2 (2012)
Available at: http://works.bepress.com/mary_lee/71/