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Temporal trends in serum concentrations of polychlorinated dioxins, furans, and PCBs among adult women living in Chapaevsk, Russia: a longitudinal study from 2000 to 2009
Open Access Articles
  • Olivier Humblet, Harvard School of Public Health
  • Oleg Sergeyev, Samara State Medical University
  • Larisa Altshul, Environmental Health and Engineering, Inc.
  • Susan A. Korrick, Harvard Medical School
  • Paige L. Williams, Harvard School of Public Health
  • Claude Emond, University of Montreal
  • Linda S. Birnbaum, National Institutes of Health
  • Jane S. Burns, Harvard University
  • Mary M. Lee, University of Massachusetts Medical School
  • Boris Revich, Russian Academy of Sciences
  • Andrey Shelepchikov, Institute of Ecology and Evolution of Russian Academy of Sciences
  • Denis Feshin, Institute of Ecology and Evolution of Russian Academy of Sciences
  • Russ Hauser, Harvard School of Public Health
UMMS Affiliation
Department of Pediatrics; Department of Cell Biology
Date
6-22-2011
Document Type
Article
Subjects
Adult; Benzofurans; Dioxins; *Environmental Exposure; Environmental Pollutants; Female; Gas Chromatography-Mass Spectrometry; Humans; Longitudinal Studies; Polychlorinated Biphenyls; Russia; Young Adult
Abstract

BACKGROUND: The present study assessed the temporal trend in serum concentrations of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls (PCBs) among residents of a Russian town where levels of these chemicals are elevated due to prior industrial activity.

METHODS: Two serum samples were collected from eight adult women (in 2000 and 2009), and analyzed with gas chromatography-high-resolution mass spectrometry.

RESULTS: The average total toxic equivalency (TEQ) decreased by 30% (from 36 to 25 pg/g lipid), and the average sum of PCB congeners decreased by 19% (from 291 to 211 ng/g lipid). Total TEQs decreased for seven of the eight women, and the sum of PCBs decreased for six of eight women. During this nine year period, larger decreases in serum TEQs and PCBs were found in women with greater increases in body mass index.

CONCLUSIONS: This study provides suggestive evidence that average serum concentrations of dioxins, furans, and PCBs are decreasing over time among residents of this town.

Rights and Permissions
Citation: Environ Health. 2011 Jun 22;10:62. Link to article on publisher's site
Comments

© 2011 Humblet et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Related Resources
Link to Article in PubMed
PubMed ID
21696632
Citation Information
Olivier Humblet, Oleg Sergeyev, Larisa Altshul, Susan A. Korrick, et al.. "Temporal trends in serum concentrations of polychlorinated dioxins, furans, and PCBs among adult women living in Chapaevsk, Russia: a longitudinal study from 2000 to 2009" Vol. 10 (2011) ISSN: 1476-069X (Linking)
Available at: http://works.bepress.com/mary_lee/66/