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Serum concentrations of organochlorine pesticides and growth among Russian boys
Lee Lab Publications
  • Jane S. Burns, Harvard School of Public Health
  • Paige L. Williams, Harvard School of Public Health
  • Oleg Sergeyev, Samara State Medical University
  • Susan Korrick, Harvard School of Public Health
  • Mary M. Lee, University of Massachusetts Medical School
  • Boris Revich, Russian Academy of Sciences
  • Larisa Altshul, Harvard School of Public Health
  • Julie T. Del Prato, Harvard School of Public Health
  • Olivier Humblet, Harvard School of Public Health
  • Donald G. Patterson, EnviroSolutions Consulting, Inc.
  • Wayman E. Turner, Centers for Disease Control and Prevention
  • Mikhail Starovoytov, Russian Institute of Nutrition
  • Russ Hauser, Harvard School of Public Health
UMMS Affiliation
Department of Pediatrics
Date
10-1-2011
Document Type
Article
Medical Subject Headings
Body Height; Body Mass Index; Child; *Child Development; *Environmental Exposure; Follow-Up Studies; Humans; Hydrocarbons, Chlorinated; Male; Multivariate Analysis; Pesticides; Prospective Studies; Russia; Sensitivity and Specificity
Abstract
BACKGROUND: Limited human data suggest an association of organochlorine pesticides (OCPs) with adverse effects on children's growth. OBJECTIVE: We evaluated the associations of OCPs with longitudinally assessed growth among peripubertal boys from a Russian cohort with high environmental OCP levels. METHODS: A cohort of 499 boys enrolled in the Russian Children's Study between 2003 and 2005 at 8-9 years of age were followed prospectively for 4 years. At study entry, 350 boys had serum OCPs measured. Physical examinations were conducted at entry and annually. The longitudinal associations of serum OCPs with annual measurements of body mass index (BMI), height, and height velocity were examined by multivariate mixed-effects regression models for repeated measures, controlling for potential confounders. RESULTS: Among the 350 boys with OCP measurements, median serum hexachlorobenzene (HCB), beta-hexachlorocyclohexane (betaHCH), and p,p -dichlorodiphenyldichloroethylene (p,p -DDE) concentrations were 159 ng/g lipid, 168 ng/g lipid, and 287 ng/g lipid, respectively. Age-adjusted BMI and height z-scores generally fell within the normal range per World Health Organization standards at entry and during follow-up. However, in adjusted models, boys with higher serum HCB, betaHCH, and p,p -DDE had significantly lower mean [95% confidence interval (CI)] BMI z-scores, by -0.84 (-1.23, -0.46), -1.32 (-1.70, -0.95), and -1.37 (-1.75, -0.98), respectively, for the highest versus lowest quintile. In addition, the highest quintile of p,p -DDE was associated with a significantly lower mean (95% CI) height z-score, by -0.69 (-1.00, -0.39) than that of the lowest quintile. CONCLUSIONS: Serum OCP concentrations measured at 8-9 years of age were associated with reduced growth, particularly reduced BMI, during the peripubertal period, which may affect attainment of optimal adult body mass and height.
Rights and Permissions
Citation: Environ Health Perspect. 2012 Feb;120(2):303-8. doi: 10.1289/ehp.1103743. Epub 2011 Oct 7. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
21984531
Citation Information
Jane S. Burns, Paige L. Williams, Oleg Sergeyev, Susan Korrick, et al.. "Serum concentrations of organochlorine pesticides and growth among Russian boys" Vol. 120 Iss. 2 (2011) ISSN: 0091-6765 (Linking)
Available at: http://works.bepress.com/mary_lee/62/