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Predictors of serum dioxin, furan, and PCB concentrations among women from Chapaevsk, Russia
Lee Lab Publications
  • Olivier Humblet, Harvard School of Public Health
  • Paige L. Williams, Harvard School of Public Health
  • Susan A. Korrick, Harvard Medical School
  • Oleg Sergeyev, Samara State Medical University
  • Claude Emond, University of Montreal
  • Linda S. Birnbaum, National Institutes of Health
  • Jane S. Burns, Harvard University
  • Larisa Altshul, Environmental Health and Engineering, Inc.
  • Donald G. Patterson, Jr., EnviroSolutions Consulting, Inc.
  • Wayman E. Turner, Centers for Disease Control and Prevention
  • Mary M. Lee, University of Massachusetts Medical School
  • Boris Revich, Russian Academy of Sciences
  • Russ Hauser, Harvard School of Public Health
UMMS Affiliation
Department of Pediatrics; Department of Cell Biology
Publication Date
Document Type
Adult; Aging; Dioxins; Environmental Pollutants; Female; Furans; Humans; Middle Aged; Multivariate Analysis; Polychlorinated Biphenyls; Russia; Young Adult

Dioxins, furans, and polychlorinated biphenyls (PCBs) are persistent and bioaccumulative toxic chemicals that are ubiquitous in the environment. We assessed predictors of their serum concentrations among women living in a Russian town contaminated by past industrial activity. Blood samples from 446 mothers aged 23-52 years were collected between 2003-2005 as part of the Russian Children's Study. Serum dioxin, furan, and PCB concentrations were quantified using high-resolution gas chromatography-mass spectrometry. Potential determinants of exposure were collected through interviews. Multivariate linear regression models were used to identify predictors of serum concentrations and toxic equivalencies (TEQs). The median total PCB concentrations and total TEQs were 260 ng/g lipid and 25 pg TEQ/g lipid, respectively. In multivariate analyses, both total PCB concentrations and total TEQs increased significantly with age, residential proximity to a local chemical plant, duration of local farming, and consumption of local beef. Both decreased with longer breastfeeding, recent increases in body mass index, and later blood draw date. These demographic and lifestyle predictors showed generally similar associations with the various measures of serum dioxins, furans, and PCBs.

DOI of Published Version
Environ Sci Technol. 2010 Jul 15;44(14):5633-40. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
Citation Information
Olivier Humblet, Paige L. Williams, Susan A. Korrick, Oleg Sergeyev, et al.. "Predictors of serum dioxin, furan, and PCB concentrations among women from Chapaevsk, Russia" Vol. 44 Iss. 14 (2010) ISSN: 0013-936X (Linking)
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