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Predictors of serum dioxins and PCBs among peripubertal Russian boys
Lee Lab
  • Jane S. Burns, Harvard School of Public Health
  • Paige L. Williams, Harvard School of Public Health
  • Oleg Sergeyev, Samara State Medical University
  • Susan Korrick, Harvard School of Public Health
  • Mary M. Lee, University of Massachusetts Medical School
  • Boris Revich, Russian Academy of Sciences
  • Larisa Altshul, Harvard School of Public Health
  • Donald G. Patterson, EnviroSolutions Consulting, Inc.
  • Wayman E. Turner, Centers for Disease Control and Prevention
  • Larry L. Needham, Centers for Disease Control and Prevention
  • Igor Saharov, Ecological Analytical Center
  • Russ Hauser, Harvard School of Public Health
UMMS Affiliation
Department of Cell Biology; Department of Pediatrics
Date
10-1-2009
Document Type
Article
Medical Subject Headings
Benzofurans; Child; Dioxins; Environmental Pollutants; Humans; Linear Models; Male; Polychlorinated Biphenyls; Puberty; Risk Factors; Russia; Tetrachlorodibenzodioxin
Disciplines
Abstract
BACKGROUND: Although sources and routes of exposure to dioxins and polychlorinated biphenyls (PCBs) have been studied, information regarding exposure among children is limited. Breast-feeding and diet are two important contributors to early life exposure. To further understand other significant contributors to childhood exposure, we studied a cohort of children from a city with high environmental dioxin levels. OBJECTIVES: We investigated predictors of serum concentrations of polychlorinated dibenzo-p-dioxins (PCDDs)/polychlorinated dibenzofurans (PCDFs)/co-planar PCBs (C-PCBs), toxic equivalents (TEQs), and PCBs among 8- to 9-year-old boys in Chapaevsk, Russia. METHODS: We used general linear regression models to explore associations of log(10)-transformed serum concentrations of PCDDs/PCDFs/C-PCBs, TEQs, and PCBs at study entry with anthropometric, demographic, geographic, and dietary factors in 482 boys in Chapaevsk, Russia. RESULTS: The median (25th, 75th percentile) concentration for total 2005 TEQs was 21.1 pg/g lipid (14.4, 33.2). Boys who were older, consumed local foods, were breast-fed longer, and whose mothers were employed at the Khimprom chemical plant (where chlorinated chemicals were produced) or gardened locally had significantly higher serum dioxins and PCBs, whereas boys with higher body mass index or more educated parents had significantly lower serum dioxins and PCBs. Boys who lived < 2 km from Khimprom had higher total TEQs (picograms per gram lipid) [adjusted mean = 30.6; 95% confidence interval (CI), 26.8-35.0] than boys who lived > 5 km away (adjusted mean = 18.8; 95% CI, 17.2-20.6). CONCLUSIONS: Our findings suggest that there are specific local sources of dioxin and PCB exposure among children in Chapaevsk including maternal gardening, consumption of locally grown food, and residential proximity to the Khimprom plant.
Rights and Permissions
Citation: Environ Health Perspect. 2009 Oct;117(10):1593-9. Epub 2009 May 14. Link to article on publisher's website
PubMed ID
20019911
Citation Information
Jane S. Burns, Paige L. Williams, Oleg Sergeyev, Susan Korrick, et al.. "Predictors of serum dioxins and PCBs among peripubertal Russian boys" Vol. 117 Iss. 10 (2009) ISSN: 1552-9924
Available at: http://works.bepress.com/mary_lee/50/