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MIS/AMH in the assessment of cryptorchidism and intersex conditions
Lee Lab Publications
  • Mary M. Lee, University of Massachusetts Medical School
  • Madhusmita Misra, Massachusetts General Hospital and Harvard Medical School
  • Patricia K. Donahoe, Massachusetts General Hospital
  • David T. MacLaughlin, Harvard Medical School
UMMS Affiliation
Department of Pediatrics
Publication Date
Document Type
Adolescent; Age Factors; Anti-Mullerian Hormone; Child; Child, Preschool; Cryptorchidism; Disorders of Sex Development; Female; Glycoproteins; Humans; Infant; Infant, Newborn; Male; Reference Values; Sex Factors; Testicular Hormones; Virilism
Mullerian inhibiting substance (MIS), also known as anti-Mullerian hormone (AMH), causes Mullerian duct involution during male sexual differentiation and also has a postnatal regulatory role in the gonads. Serum MIS/AMH has a gonad specific pattern of expression and its concentrations are sexually dimorphic in children; hence measurement of serum MIS/AMH helps in the evaluation of children with gonadal disorders. In boys with cryptorchidism (non-palpable gonads), serum MIS/AMH correlates with testicular tissue. A measurable value is predictive of undescended testes while an undetectable value is highly suggestive of anorchia. In minimally virilized phenotypic females, MIS/AMH helps differentiate between gonadal and non-gonadal causes of virilization. In children with intersex conditions, MIS/AMH values assist differential diagnosis: a value above the normal female range is predictive of testicular tissue, while an undetectable value is suggestive of absent testicular tissue. Thus, MIS/AMH is useful for delineating gonadal pathology and facilitates the differential diagnosis and management of children with diverse gonadal disorders.
DOI of Published Version
Mol Cell Endocrinol. 2003 Dec 15;211(1-2):91-8. Link to publisher's site.

At the time of publication, Mary Lee was not yet affiliated with the University of Massachusetts Medical School.

Related Resources
Link to Article in PubMed
PubMed ID
Citation Information
Mary M. Lee, Madhusmita Misra, Patricia K. Donahoe and David T. MacLaughlin. "MIS/AMH in the assessment of cryptorchidism and intersex conditions" Vol. 211 Iss. 1-2 (2003) ISSN: 0303-7207 (Linking)
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