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Article
Vitamin D status is associated with early markers of cardiovascular disease in prepubertal children
Endocrinology/Diabetes
  • Benjamin U. Nwosu, University of Massachusetts Medical School
  • Louise Maranda, University of Massachusetts Medical School
  • Karen Cullen, University of Massachusetts Medical School
  • Carol A. Ciccarelli, University of Massachusetts Medical School
  • Mary M. Lee, University of Massachusetts Medical School
UMMS Affiliation
Department of Pediatrics; Department of Quantitative Health Sciences; Department of Cell and Developmental Biology
Publication Date
7-2-2013
Document Type
Article
Subjects
Vitamin D; Cardiovascular Diseases; Child; Biological Markers
Abstract

Background: The associations of 25-hydroxyvitamin D [25(OH)D], non-high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL), and related markers of early cardiovascular disease (CVD) are unclear in prepubertal children.

Objective: To investigate the association of 25(OH)D with markers of CVD. The hypothesis was that 25(OH)D would vary inversely with non-HDL-C.

Subjects and methods: A prospective cross-sectional study of children (n=45; 26 males, 19 females) of mean age 8.3 ± 2.5 years to investigate the relationships between 25(OH)D and glucose, insulin, high-sensitivity C-reactive protein, and lipids. Vitamin D deficiency was defined as 25(OH)D/mL; overweight as body mass index (BMI) ≥ 85 th but <95th >percentile; and obesity as BMI >95th percentile.

Results: Twenty subjects (44.4%) had BMI30 ng/mL. Patients with 25(OH)D of/mL had significantly elevated non-HDL-C (136.08 ± 44.66 vs. 109.88 ± 28.25, p=0.025), total cholesterol (TC)/HDL ratio (3.89 ± 1.20 vs. 3.21 ± 0.83, p=0.042), and triglycerides (TG) (117.09 ± 71.27 vs. 73.39 ± 46.53, p=0.024), while those with 25(OH)D of >30 ng/mL had significantly lower non-HDL-C, TC/HDL, TG, and LDL (82.40 ± 18.03 vs. 105.15 ± 28.38, p=0.006). Multivariate analysis showed significant inverse correlations between 25(OH)D and non-HDL cholesterol (β=-0.337, p=0.043), and TC/HDL ratio (β=-0.339, p=0.028), and LDL (β=-0.359, p=0.016), after adjusting for age, race, sex, BMI, and seasonality.

Conclusions: Vitamin D varied inversely with non-HDL, TC/HDL, and LDL. A 25(OH)D level of 30 ng/mL is associated with optimal cardioprotection in children.

Rights and Permissions

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DOI of Published Version
10.1515/jpem-2013-0086
Source

Nwosu BU, Maranda L, Cullen K, Ciccarelli C, Lee MM. Vitamin D status is associated with early markers of cardiovascular disease in prepubertal children. J Pediatr Endocrinol Metab. 2013;26(11-12):1067-75. doi: 10.1515/jpem-2013-0086. The final publication is available at www.degruyter.com. Link to article on publisher's website

Related Resources
Link to article in PubMed
PubMed ID
23817598
Citation Information
Benjamin U. Nwosu, Louise Maranda, Karen Cullen, Carol A. Ciccarelli, et al.. "Vitamin D status is associated with early markers of cardiovascular disease in prepubertal children" Vol. 26 Iss. 11-12 (2013) ISSN: 0334-018X
Available at: http://works.bepress.com/mary_lee/22/