Blood lead levels and delayed onset of puberty in a longitudinal study of Russian boysLee Lab Publications
UMMS AffiliationDepartment of Pediatrics; Department of Cell Biology
Medical Subject HeadingsAdolescent; Body Size; Child; Cohort Studies; Food Habits; Health Surveys; Humans; Lead; Lead Poisoning; Longitudinal Studies; Male; Proportional Hazards Models; Puberty, Delayed; Russia; Sexual Maturation; Socioeconomic Factors
AbstractOBJECTIVE: We evaluated the association of blood lead levels (BLLs) with pubertal onset in a longitudinal cohort of Russian boys. METHODS: A total of 489 Russian boys were enrolled in 2003-2005, at 8 to 9 years of age, and were monitored annually through May 2008. Cox proportional-hazards models were used to evaluate the association of BLLs at enrollment with time to pubertal onset during follow-up monitoring. RESULTS: A total of 481 boys had BLLs, with a median of 3 microg/dL and 28% with values of > or =5 microg/dL. The proportion of pubertal boys increased with age, from 12% at age 8 to 83% at age 12 for testicular volume of >3 mL, from 22% to 90% for genitalia stage 2 or higher, and from 4% to 40% for pubic hair stage 2 or higher. After adjustment for potential confounders including BMI and height, boys with high BLLs (> or =5 microg/dL) had 24% to 31% reduced risk of pubertal onset, on the basis of testicular volume of >3 mL (hazard ratio [HR]: 0.73 [95% confidence interval [CI]: 0.55-0.97]; P = .03), genitalia staging (HR: 0.76 [95% CI: 0.59-0.98]; P = .04), and pubic hair staging (HR: 0.69 [95% CI: 0.44-1.07]; P = .10), compared with those with lower BLLs. Pubertal onset occurred 6 to 8 months later, on average, for boys with high BLLs, compared with those with BLLs of <5 microg>/dL. CONCLUSION: Higher BLLs were associated with later pubertal onset in this prospective study of peripubertal Russian boys.
Rights and PermissionsCitation: Pediatrics. 2010 May;125(5):e1088-96. Epub 2010 Apr 5. Link to article on publisher's site
Related ResourcesLink to Article in PubMed
Citation InformationPaige L. Williams, Oleg Sergeyev, Mary M. Lee, Susan A. Korrick, et al.. "Blood lead levels and delayed onset of puberty in a longitudinal study of Russian boys" Vol. 125 Iss. 5 (2010) ISSN: 0031-4005 (Linking)
Available at: http://works.bepress.com/mary_lee/19/