About Mary M. Lee
Mary M. Lee, M.D. is the Chair and Professor of Pediatrics and Cell & Developmental Biology and Chair, Department of Pediatrics, at the University of Massachusetts Medical School. She is also Physician-in-Chief for the UMass Memorial Children’s Medical Center. Her research focuses on understanding the role of Mullerian inhibiting substance in the testis and elucidating the hormonal and cellular interactions that are critical for testicular development. The research involves both clinical investigations and laboratory studies. The basic research efforts have focused on clarifying the paracrine and endocrine regulation of Leydig cell differentiation and on identifying the effects of persistent organic pollutants (endocrine disruptors, such as dioxins) on the developing male reproductive system. Areas of research interest: Biology and regulation of Mullerian inhibiting substance; Sexual differentiation and intersex disorders; Testicular differentiation and development (fetal and postnatal) of Leydig cells; the effects of environmental toxins on reproductive development; Gonadal toxicity of chemotherapy and radiation for childhood malignancies.
|Present||Chair, University of Massachusetts Medical School ‐ Department of Pediatrics|
|Present||Chief, Pediatric Endocrine Division, Department of Pediatrics, University of Massachusetts Medical School|
|Present||Co-Director of Clinical and Translational Research, Diabetes Center of Excellence, University of Massachusetts Medical School|
|Present||Physician-in-Chief, UMass Memorial Children’s Medical Center, UMass Memorial Health Care Center|
|Professor of Pediatrics and Cell & Developmental Biology, University of Massachusetts Medical School|
Pediatric endocrinology and Reproductive development
Honors and Awards
- External Scientific Advisory Board, Breast Cancer and the Environment Research Programs, Multi-center research consortium funded by NIEHS and NCI (2010-2014)
- National Advisory Scientific Council, National Institute of Environmental Health Sciences (2010-2014)
- Best Doctors of America (2005-2014)
Department of Pediatrics
University of Massachusetts Medical School
55 Lake Avenue North
Worcester, MA 01655
Phone (508) 856-3199
Intervention Fidelity: Monitoring Drift, Providing Feedback, and Assessing the Control ...
University of Massachusetts Medical School Faculty Publications (2017)
BACKGROUND: Measurement of intervention fidelity is an essential component of any scientifically sound intervention trial. However, few papers have proposed ...
A Longitudinal Study of Peripubertal Serum Organochlorine Concentrations and Semen ...
Pediatric Publications and Presentations (2016)
BACKGROUND: Exposures to endocrine disrupting chemicals during critical phases of testicular development may be related to poorer semen parameters. However, ...
Associations of Peripubertal Serum Dioxin and Polychlorinated Biphenyl Concentrations with ...
Cell and Developmental Biology Publications (2016)
BACKGROUND: Dioxins, furans, and polychlorinated biphenyls (PCBs), dioxin-like and nondioxin-like, have been linked to alterations in puberty. OBJECTIVES: We examined ...
Prepubertal organochlorine pesticide concentrations and age of pubertal onset among ...
BACKGROUND: In animal studies, organochlorine pesticide (OCP) exposure alters pubertal development; however, epidemiological data are limited and inconsistent. OBJECTIVE: To ...
Predictors of serum chlorinated pesticide concentrations among prepubertal Russian boys
Lee Lab Publications (2013)
BACKGROUND: Few studies have evaluated predictors of childhood exposure to organochlorine pesticides (OCPs), a class of lipophilic persistent chemicals. OBJECTIVES: ...
Vitamin D status is associated with early markers of cardiovascular ...
Background: The associations of 25-hydroxyvitamin D [25(OH)D], non-high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL), and related markers of early cardiovascular ...
Genetic modification of the association between peripubertal dioxin exposure and ...
Cell and Developmental Biology Publications (2013)
BACKGROUND: Exposure to dioxins has been associated with delayed pubertal onset in both epidemiologic and animal studies. Whether genetic polymorphisms ...