Background:Merged healthcare settings, particularly those with Magnet designated sites, present distinct opportunities for PhD nurse scientists developing nursing research infrastructure.

Purpose:This article aims to assist nurse scientists and healthcare leaders in defining nurse scientist roles, and in developing research infrastructure for conducting multi-site research in merged settings.

Method:Practical strategies and a framework are provided to assist in building and navigating nurse scientist roles and research infrastructure development.

Discussion:Emphasizing the necessity of organizational support, the article underscores the importance of clear role delineation and leadership support.

Conclusion:To optimize the contributions of nurse scientists in merged healthcare settings, especially in Magnet organizations, clear role definitions, robust research infrastructure, and strong organizational support are imperative.