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Dynamics of Prebiotic RNA Reproduction Illuminated by Chemical Game Theory
Proceedings of the National Academy of Sciences of the United States of America
  • Jessica Anne Mellor Yeates, Portland State University
  • Christian Hilbe, Harvard University
  • Martin Zwick, Portland State University
  • Martin. A. Nowak, Harvard University
  • Niles Lehman, Portland State University
Document Type
Citation
Publication Date
5-3-2016
Disciplines
Abstract
Many origins-of-life scenarios depict a situation in which there are common and potentially scarce resources needed by molecules that compete for survival and reproduction. The dynamics of RNA assembly in a complex mixture of sequences is a frequency-dependent process and mimics such scenarios. By synthesizing Azoarcus ribozyme genotypes that differ in their single-nucleotide interactions with other genotypes, we can create molecules that interact among each other to reproduce. Pairwise interplays between RNAs involve both cooperation and selfishness, quantifiable in a 2 × 2 payoff matrix. We show that a simple model of differential equations based on chemical kinetics accurately predicts the outcomes of these molecular competitions using simple rate inputs into these matrices. In some cases, we find that mixtures of different RNAs reproduce much better than each RNA type alone, reflecting a molecular form of reciprocal cooperation. We also demonstrate that three RNA genotypes can stably coexist in a rock–paper–scissors analog. Our experiments suggest a new type of evolutionary game dynamics, called prelife game dynamics or chemical game dynamics. These operate without template-directed replication, illustrating how small networks of RNAs could have developed and evolved in an RNA world.
DOI
10.1073/pnas.1525273113
Persistent Identifier
http://archives.pdx.edu/ds/psu/18855
Citation Information
Yeates, J. A., Hilbe, C., Zwick, M., Nowak, M. A., & Lehman, N. (2016). Dynamics of prebiotic RNA reproduction illuminated by chemical game theory. Proceedings of the National Academy of Sciences, 113(18), 5030-5035.