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Accelerating the Development of 21st-Century Toxicology: Outcome of a Human Toxicology Project Consortium Workshop
in Vitro Research Models Collection
  • Martin L. Stephens, The Humane Society of the United States
  • Craig Barrow, Craig Barrow Consulting
  • Melvin E. Andersen, The Hamner Institutes for Health Sciences
  • Kim Boekelheide, Brown University
  • Paul L. Carmichael, Unilever
  • Michael P. Holsapple, ILSI Health and Environmental Sciences Institute
  • Mark Lafranconi, The Procter & Gamble Company
Document Type
Article
Publication Date
2-1-2012
Abstract

The U.S. National Research Council (NRC) report on “Toxicity Testing in the 21st century” calls for a fundamental shift in the way that chemicals are tested for human health effects and evaluated in risk assessments. The new approach would move toward in vitro methods, typically using human cells in a high-throughput context. The in vitro methods would be designed to detect significant perturbations to “toxicity pathways,” i.e., key biological pathways that, when sufficiently perturbed, lead to adverse health outcomes. To explore progress on the report’s implementation, the Human Toxicology Project Consortium hosted a workshop on 9–10 November 2010 in Washington, DC. The Consortium is a coalition of several corporations, a research institute, and a non-governmental organization dedicated to accelerating the implementation of 21st-century Toxicology as aligned with the NRC vision. The goal of the workshop was to identify practical and scientific ways to accelerate implementation of the NRC vision. The workshop format consisted of plenary presentations, breakout group discussions, and concluding commentaries. The program faculty was drawn from industry, academia, government, and public interest organizations. Most presentations summarized ongoing efforts to modernize toxicology testing and approaches, each with some overlap with the NRC vision. In light of these efforts, the workshop identified recommendations for accelerating implementation of the NRC vision, including greater strategic coordination and planning across projects (facilitated by a steering group), the development of projects that test the proof of concept for implementation of the NRC vision, and greater outreach and communication across stakeholder communities.

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Citation Information
Stephens, M. L., Barrow, C., Andersen, M. E., Boekelheide, K., Carmichael, P. L., Holsapple, M. P., & Lafranconi, M. (2011). Accelerating the development of 21st-century toxicology: outcome of a Human Toxicology Project Consortium workshop. Toxicological Sciences, 125(2), 327-334. DOI https://doi.org/10.1093/toxsci/kfr248