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The impact of abnormal glucose tolerance and obesity on fetal growth
Journal of Diabetes Research
  • Erin Graves, Western University
  • David J. Hill, Western University
  • Susan Evers, University of Guelph
  • Kristine Van Aarsen, Western University
  • Brie Yama, Western University
  • Su Yuan, Western University
  • M. Karen Campbell, Western University
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Factors linked with insulin resistance were examined for their association with large-for-gestational-age (LGA) infant birth weight and gestational diabetes. Study Design. Data came from a longitudinal cohort study of 2,305 subjects without overt diabetes, analyzed using multinomial logistic and linear regression. Results. High maternal BMI (OR = 1.53 (1.11, 2.12)), height (1.98 (1.62, 2.42)), antidepressant use (1.71 (1.20, 2.44)), pregnancy weight-gain exceeding 40 pounds (1.79 (1.25, 2.57)), and high blood sugar (2.68, (1.53, 5.27)) were all positively associated with LGA birth. Strikingly, the difference in risk from diagnosed and treated gestational diabetes compared to women with a single abnormal glucose tolerance test (but no diagnosis of gestational diabetes) was significant (OR = 0.65, p = 0.12 versus OR = 2.84, p < 0.01). When weight/length ratio was used instead, different factors were found to be significant. BMI and pregnancy weight-gain were found to influence the development of gestational diabetes, through an additive interaction. Conclusions. High prepregnancy BM, height, antidepressant use, pregnancy weight-gain exceeding 40 pounds, and high blood sugar were associated with LGA birth, but not necessarily infant weight/length ratio. An additive interaction between BMI and pregnancy weight-gain influenced gestational diabetes development.

Citation Information
Erin Graves, David J. Hill, Susan Evers, Kristine Van Aarsen, et al.. "The impact of abnormal glucose tolerance and obesity on fetal growth" Journal of Diabetes Research Vol. 2015 (2015)
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