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Article
The Functional Neuroanatomy of Object Agnosia: A Case Study
Neuron
  • Christina S. Konen, Princeton University
  • Marlene Behrmann, Carnegie Mellon University
  • Mayu Nishimura, Carnegie Mellon University
  • Sabine Kastner, Princeton University
Disciplines
Date of Original Version
7-14-2011
Type
Article
Abstract or Description
Cortical reorganization of visual and object representations following neural injury was examined using fMRI and behavioral investigations. We probed the visual responsivity of the ventral visual cortex of an agnosic patient who was impaired at object recognition following a lesion to the right lateral fusiform gyrus. In both hemispheres, retinotopic mapping revealed typical topographic organization and visual activation of early visual cortex. However, visual responses, object-related, and -selective responses were reduced in regions immediately surrounding the lesion in the right hemisphere, and also, surprisingly, in corresponding locations in the structurally intact left hemisphere. In contrast, hV4 of the right hemisphere showed expanded response properties. These findings indicate that the right lateral fusiform gyrus is critically involved in object recognition and that an impairment to this region has widespread consequences for remote parts of cortex. Finally, functional neural plasticity is possible even when a cortical lesion is sustained in adulthood
DOI
10.1016/j.neuron.2011.05.030
Citation Information
Christina S. Konen, Marlene Behrmann, Mayu Nishimura and Sabine Kastner. "The Functional Neuroanatomy of Object Agnosia: A Case Study" Neuron Vol. 71 Iss. 1 (2011) p. 49 - 60
Available at: http://works.bepress.com/marlene_behrmann/97/