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Article
Targeted Maximum Likelihood Based Causal Inference: Part II
The International Journal of Biostatistics (2010)
  • Mark J. van der Laan, University of California - Berkeley
Abstract
In this article, we provide a template for the practical implementation of the targeted maximum likelihood estimator for analyzing causal effects of multiple time point interventions, for which the methodology was developed and presented in Part I. In addition, the application of this template is demonstrated in two important estimation problems: estimation of the effect of individualized treatment rules based on marginal structural models for treatment rules, and the effect of a baseline treatment on survival in a randomized clinical trial in which the time till event is subject to right censoring.
Keywords
  • causal effect,
  • causal graph,
  • censored data,
  • cross-validation,
  • collaborative double robust,
  • double robust,
  • dynamic treatment regimens,
  • efficient influence curve,
  • estimating function,
  • estimator selection,
  • locally efficient,
  • loss function,
  • marginal structural models for dynamic treatments,
  • maximum likelihood estimation,
  • model selection,
  • path-wise derivative,
  • randomized controlled trials,
  • sieve,
  • super-learning,
  • targeted maximum likelihood estimation
Publication Date
2010
Citation Information
Mark J. van der Laan. "Targeted Maximum Likelihood Based Causal Inference: Part II" The International Journal of Biostatistics Vol. 6 Iss. 2 (2010)
Available at: http://works.bepress.com/mark_van_der_laan/262/