The purpose of this report is to provide a framework for the prioritization of water bodies in the Columbia River Basin and the Greater Northwest region (surrounding areas in Oregon, Washington, California, Nevada, Idaho, Utah, and Wyoming) for early detection monitoring for dreissenid mussels. Our ability to assess the relative risk of establishment and introduction of dreissenid mussels was confounded by significant gaps in the data necessary to rigorously predict where dreissenid mussels will become introduced and subsequently established. Consequently, local jurisdictions should evaluate the prioritized lists provided critically and make adjustments where local knowledge and additional information dictates. Further, since invasive species can be introduced and become established in areas identified with low to very low risk of establishment and introduction, monitoring these areas will increase the probability of detecting mussels before they become locally established.