To evade signature-based detection, metamorphic viruses transform their code before each new infection. Software similarity measures are a potentially useful means of detecting such malware. We can compare a given file to a known sample of metamorphic malware and compute their similarity—if they are sufficiently similar, we classify the file as malware of the same family. In this paper, we analyze an opcode-based software similarity measure inspired by simple substitution cipher cryptanalysis. We show that the technique provides a useful means of classifying metamorphic malware.