Skip to main content
Article
Reduction of Pulmonary Mast Cells in Areas of Acute Inflammation in Calves with Mannheimia (Pasteurella) haemolytica Pneumonia
Journal of Comparative Pathology
  • Rafael Ramírez-Romero, Iowa State University
  • Kim A. Brogden, United States Department of Agriculture
  • Jack M. Gallup, Iowa State University
  • Richard A. Dixon, Texas Biotechnology Corporation
  • Mark R. Ackermann, Iowa State University
Document Type
Article
Publication Date
7-1-2000
DOI
10.1053/jcpa.1999.0383
Abstract
Mast cells in the left cranial pulmonary lobe of colostrum-deprived neonatal calves were quantified 2 and 6 h after intrabronchial inoculation with Mannheimia (Pasteurella) haemolytica A1. The mast cells were detected (1) immunohistochemically with a mouse anti-human mast cell tryptase monoclonal antibody, and (2) by metachromatic staining with low pH toluidine blue. A greater number of mast cells was demonstrated by the second method than by the first. At 6 h after inoculation, but not at 2 h, the number of mast cells was significantly reduced at the site of the main lesions. Treatment of calves with a sialyl Lewis mimetic (TBC1269) did not appreciably affect the results at 6 h.
Comments

This article is from Journal of Comparative Pathology 123, no 1 (July 2000): 29–35, doi:10.1053/jcpa.1999.0383.

Rights
Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.
Language
en
Date Available
February 26, 2013
File Format
application/pdf
Citation Information
Rafael Ramírez-Romero, Kim A. Brogden, Jack M. Gallup, Richard A. Dixon, et al.. "Reduction of Pulmonary Mast Cells in Areas of Acute Inflammation in Calves with Mannheimia (Pasteurella) haemolytica Pneumonia" Journal of Comparative Pathology Vol. 123 Iss. 1 (2000) p. 29 - 35
Available at: http://works.bepress.com/mark_ackermann/45/