Reduction of Pulmonary Mast Cells in Areas of Acute Inflammation in Calves with Mannheimia (Pasteurella) haemolytica PneumoniaJournal of Comparative Pathology
AbstractMast cells in the left cranial pulmonary lobe of colostrum-deprived neonatal calves were quantified 2 and 6 h after intrabronchial inoculation with Mannheimia (Pasteurella) haemolytica A1. The mast cells were detected (1) immunohistochemically with a mouse anti-human mast cell tryptase monoclonal antibody, and (2) by metachromatic staining with low pH toluidine blue. A greater number of mast cells was demonstrated by the second method than by the first. At 6 h after inoculation, but not at 2 h, the number of mast cells was significantly reduced at the site of the main lesions. Treatment of calves with a sialyl Lewis mimetic (TBC1269) did not appreciably affect the results at 6 h.
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Citation InformationRafael Ramírez-Romero, Kim A. Brogden, Jack M. Gallup, Richard A. Dixon, et al.. "Reduction of Pulmonary Mast Cells in Areas of Acute Inflammation in Calves with Mannheimia (Pasteurella) haemolytica Pneumonia" Journal of Comparative Pathology Vol. 123 Iss. 1 (2000) p. 29 - 35
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