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Article
The Genetic Immunodeficiency Disease, Leukocyte Adhesion Deficiency, in Humans, Dogs, Cattle, and Mice
Comparative Medicine
  • Yu-chen Gu, National Institutes of Health
  • Thomas R. Bauer, Jr., National Institutes of Health
  • Mark R. Ackermann, Iowa State University
  • C. Wayne Smith, Baylor College of Medicine
  • Marcus E. Kehrli, Jr., United States Department of Agriculture
  • Matthew F. Starost, National Institutes of Health
  • Dennis D. Hickstein, National Institutes of Health
Document Type
Article
Publication Date
8-1-2004
Abstract
This review highlights the genotype-phenotype relationship of the genetic immunodeficiency disease leukocyte adhesion deficiency (LAD) in humans, dogs, cattle, and mice, and provides assessment of the opportunities that each animal species provides in the understanding of leukocyte biology and in developing new therapeutic approaches to LAD in humans. This comparison is important since animal models of genetic diseases in humans provide the opportunity to test new therapeutic approaches in an appropriate, disease-specific model. The success of this approach is dependent on the relationship of the phenotype in the animal to the phenotype of the disease in humans.
Comments

This article is from Comparative Medicine 54, no. 4 (August 2004): 363–372.

Rights
Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.
Language
en
Date Available
February 26, 2013
File Format
application/pdf
Citation Information
Yu-chen Gu, Thomas R. Bauer, Mark R. Ackermann, C. Wayne Smith, et al.. "The Genetic Immunodeficiency Disease, Leukocyte Adhesion Deficiency, in Humans, Dogs, Cattle, and Mice" Comparative Medicine Vol. 54 Iss. 4 (2004) p. 363 - 372
Available at: http://works.bepress.com/mark_ackermann/27/