Article
Antimicrobial activity of cathelicidins BMAP28, SMAP28, SMAP29, and PMAP23 against Pasteurella multocida is more broad-spectrum than host species specific
Veterinary Microbiology
Document Type
Article
Disciplines
Publication Date
1-17-2007
DOI
10.1016/j.vetmic.2006.08.005
Abstract
The antimicrobial activity of linear, cationic α-helical peptides from cattle (BMAP28), sheep (SMAP28 and SMAP29), and pigs (PMAP23) were assessed to determine if activity was selective for Pasteurella multocida from a particular animal species or broad-spectrum against all P. multocida tested. The antimicrobial activities of synthetic peptides were determined for P. multocida isolated from cattle (10 isolates), sheep (10 isolates), and pigs (10 isolates) in a broth microdilution assay. All thirty isolates of P. multocida were susceptible to BMAP28 (MICs and MBCs, 1.0–1.9 μM); SMAP28 and SMAP29 (MICs and MBCs, 0.2–0.7 μM); and PMAP23 (MICs and MBCs, 4.3 to ≥6.8 μM). Overall, the results of this study suggest that synthesized cathelicidins from cattle, sheep, and pigs had broad-spectrum antimicrobial activity against all P. multocida.
Rights
Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.
Language
en
File Format
application/pdf
Citation Information
Kim A. Brogden, Gwen E. Nordholm and Mark R. Ackermann. "Antimicrobial activity of cathelicidins BMAP28, SMAP28, SMAP29, and PMAP23 against Pasteurella multocida is more broad-spectrum than host species specific" Veterinary Microbiology Vol. 119 Iss. 1 (2007) p. 76 - 81 Available at: http://works.bepress.com/mark_ackermann/14/
This article is from Veterinary Microbiology 119, no. 1 (January 2007): 76–81, doi:10.1016/j.vetmic.2006.08.005.