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Article
Coordinated Expression of Tracheal Antimicrobial Peptide and Inflammatory-Response Elements in the Lungs of Neonatal Calves with Acute Bacterial Pneumonia
Infection and Immunity
  • Jessica M. Caverly, Iowa State University
  • Gill Diamond, University of Medicine and Dentistry of New Jersey
  • Jack M. Gallup, Iowa State University
  • Kim A. Brogden, United States Department of Agriculture
  • Richard A. Dixon, Texas Biotechnology Corporation
  • Mark R. Ackermann, Iowa State University
Document Type
Article
Publication Date
5-1-2003
DOI
10.1128/​IAI.71.5.2950-2955.2003
Abstract

Lung tissue removed from neonatal calves with acute Mannheimia haemolyticapneumonia showed that rapid up-regulation of the basal mRNA expression of tracheal antimicrobial peptide (TAP), NF-κB, and intercellular adhesion molecule 1 occurred after infection; TAP and interleukin 8 expression were highly correlated. This work suggests that the coordinated expression of β-defensin and inflammatory elements occurs during bacterial pneumonia.

Comments

This article is from Infection and Immunity 71, no. 5 (May 2003): 2950–2955, doi:10.1128/IAI.71.5.2950-2955.2003.

Copyright Owner
American Society for Microbiology
Language
en
Date Available
February 25, 2013
File Format
application/pdf
Citation Information
Jessica M. Caverly, Gill Diamond, Jack M. Gallup, Kim A. Brogden, et al.. "Coordinated Expression of Tracheal Antimicrobial Peptide and Inflammatory-Response Elements in the Lungs of Neonatal Calves with Acute Bacterial Pneumonia" Infection and Immunity Vol. 71 Iss. 5 (2003) p. 2950 - 2955
Available at: http://works.bepress.com/mark_ackermann/1/