Clinical medicine and prevention in primary care practice are the themes of this issue, wherein we present new research with practical information on common subjects: cardiovascular outcomes with specific medications, vitamin D, calcium supplements, vaginitis, smoking, stroke and allergies, headaches and depression, hepatitis C, skin infections, general prevention examinations, sore throat, laboratory results notification, and patient medication lists. Looks like a typical day in the family medicine office! Although most of the authors are from university family medicine departments and residency programs,1–10 we also welcome contributions with implications for primary care from others outside the field.11–13