The Clinical Laboratory Improvement Amendments are affecting the office practice of many family physicians. While the cost of these regulations was supposed to be low, many family physicians have found them to be burdensome and costly; for some, it means the end of their office laboratories, formerly a source of income and increased convenience and quality for the patient.1 Furthermore,many physicians question the scientific basis of many aspects of these regulations2 and feel they are more a hindrance than a help.