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A mathematical model for the onset of avascular tumor growth in response to the loss of p53 function
Cancer Informatics
  • Howard A. Levine, Iowa State University
  • Michael W. Smiley, Iowa State University
  • Anna L. Tucker, Iowa State University
  • Marit Nilsen-Hamilton, Iowa State University
Document Type
Article
Publication Version
Published Version
Publication Date
1-1-2006
Abstract
We present a mathematical model for the formation of an avascular tumor based on the loss by gene mutation of the tumor suppressor function of p53. The wild type p53 protein regulates apoptosis, cell expression of growth factor and matrix metalloproteinase, which are regulatory functions that many mutant p53 proteins do not possess. The focus is on a description of cell movement as the transport of cell population density rather than as the movement of individual cells. In contrast to earlier works on solid tumor growth, a model is proposed for the initiation of tumor growth. The central idea, taken from the mathematical theory of dynamical systems, is to view the loss of p53 function in a few cells as a small instability in a rest state for an appropriate system of differential equations describing cell movement. This instability is shown (numerically) to lead to a second, spatially inhomogeneous, solution that can be thought of as a solid tumor whose growth is nutrient diffusion limited. In this formulation, one is led to a system of nine partial differential equations. We show computationally that there can be tumor states that coexist with benign states and that are highly unstable in the sense that a slight increase in tumor size results in the tumor occupying the sample region while a slight decrease in tumor size results in its ultimate disappearance.
Comments

This is an article from Cancer Informatics 2 (2006): 163. Posted with permission.

Rights
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright Owner
The authors
Language
en
File Format
application/pdf
Citation Information
Howard A. Levine, Michael W. Smiley, Anna L. Tucker and Marit Nilsen-Hamilton. "A mathematical model for the onset of avascular tumor growth in response to the loss of p53 function" Cancer Informatics Vol. 2 (2006) p. 163 - 188
Available at: http://works.bepress.com/marit-nilsen-hamilton/6/