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Characterization of a cDNA Clone Encoding Murine Mitogen-Regulated Protein: Regulation of mRNA Levels in Mortal and Immortal Cell Lines
Molecular and Cellular Biology
  • Craig L. Parfett, University of Western Ontario
  • Richard T. Hamilton, Iowa State University
  • Brian W. Howell, University of Western Ontario
  • Dylan R. Edwards, University of Western Ontario
  • Marit Nilsen-Hamilton, Iowa State University
  • David T. Denhardt, University of Western Ontario
Document Type
Article
Disciplines
Publication Version
Published Version
Publication Date
1-1-1985
DOI
10.1128/MCB.5.11.3289
Abstract
Mitogen-regulated protein (MRP) is secreted by certain immortal murine cell lines (Swiss 3T3, BNL) stimulated with serum or particular growth factors. We have identified a cDNA clone that encodes part of the protein and have confirmed that MRP is closely related to, if not identical to, the prolactin-related protein designated proliferin. MRP is not produced by primary mouse embryo fibroblasts to nearly the same extent as it is produced by many immortal or transformed lines. Control of expression of this protein by growth factors is achieved both by regulating the extent of transcription and by regulating the processing of the protein.
Comments

This is an article from Molecular and Cellular Biology 5 (1985): 3289, doi:10.1128/MCB.5.11.3289. Posted with permission.

Copyright Owner
American Society for Microbiology
Language
en
File Format
application/pdf
Citation Information
Craig L. Parfett, Richard T. Hamilton, Brian W. Howell, Dylan R. Edwards, et al.. "Characterization of a cDNA Clone Encoding Murine Mitogen-Regulated Protein: Regulation of mRNA Levels in Mortal and Immortal Cell Lines" Molecular and Cellular Biology Vol. 5 Iss. 11 (1985) p. 3289 - 3292
Available at: http://works.bepress.com/marit-nilsen-hamilton/5/