Skip to main content
Unpublished Paper
Secreted proteins induced by growth factors and inhibitors
Cell Biology International Reports
  • Marit Nilsen-Hamilton, Iowa State University
  • Richard T. Hamilton, Iowa State University
Document Type
Article
Disciplines
Publication Version
Published Version
Publication Date
1-1-1983
DOI
10.1016/0309-1651(83)90161-3
Abstract

We have shown that serum, fibroblast growth factor, epidermal growth factor, and the tumour promotor, 12-O-tetradecanoylphorbol- 13-acetate (TPA), selectively induce the synthesis of certain secreted proteins in a variety of cell types. Similarly, a specific growth inhibitor protein selectively induces the synthesis of a secreted protein that is different from those induced by growth factors. In each case, the average increase in labeling by [3%]methionine of these secreted proteins after their induction is 7- to 10-fold. No correspondingly large increase is detected for intracellular proteins.

Comments

This is an article from Cell Biology International Reports 7 (1983): 527, doi:10.1016/0309-1651(83)90161-3. Posted with permission.

Rights
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright Owner
The Authors
Language
en
File Format
application/pdf
Citation Information
Marit Nilsen-Hamilton and Richard T. Hamilton. "Secreted proteins induced by growth factors and inhibitors" Cell Biology International Reports Vol. 7 Iss. 7 (1983) p. 527 - 528
Available at: http://works.bepress.com/marit-nilsen-hamilton/23/